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These effects, along with a prior report displaying that a small-molecule ACKR3 agonist CCX771 reveals anxiolytic-like conduct in mice,two help the notion of targeting ACKR3 as a unique strategy to modulate the opioid process, which could open up new therapeutic avenues for opioid-related Problems.Tabernaemontana divaricata Conolidine can be an ind